Searchable abstracts of presentations at key conferences in endocrinology

ea0029p118 | Adrenal medulla | ICEECE2012

Geranylgeraniols are essential for adrenal catecholamine secretion

Tachikawa E. , Kutsukake M. , Tamura K. , Yosie M. , Hossain M. , Taira H.

Introduction: Dolichols are isoprenoids, which are synthesized from acetyl-CoA via mevalonic acid, and they are known to be abundant in endocrine system. Adrenal medulla, which is not only an endocrine organ but also an organ derived from neural crest, secrets catecholamines via sodium and subsequent calcium influxes into the cells through nicotinic ACh receptor-operated cation channels and voltage-sensitive calcium channels, respectively, when the medulla is stimulated by ace...

ea0029p1168 | Nuclear receptors and Signal transduction | ICEECE2012

PPARγ activator may improve sepsis symptom by inhibiting inflammation in adipose tissue

Kutsukake M. , Kobayashi M. , Tamura K. , Yoshie M. , Tachikawa E. , Matsuda A. , Uchida E. , Matsutani T.

Introduction: Postoperative sepsis exhibits high mortality. Prevention of postoperative infection and palliation of sepsis symptom are important issues in the patient’s care after surgical operation. Adipose tissue as an endocrine organ that secretes various cytokines. Circulating adiponectin, an anti-inflammatory cytokine, and inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α are derived partially from adipose tissues. Recent studie...